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Symbol Name ID |
Smad4
SMAD family member 4 MGI:894293 |
| Darker colors indicate more annotations |
| Human Phenotypes | Cerebral hemorrhage |
Subarachnoid hemorrhage |
Cerebral arteriovenous malformation |
Spinal arteriovenous malformation |
Abnormal cerebral vascular morphology |
Stroke |
Ischemic stroke |
Transient ischemic attack |
Anorexia |
Pituitary adenoma |
Brain abscess |
Glioblastoma multiforme |
Benign neoplasm of the central nervous system |
Neuroblastoma |
Abnormal pyramidal sign |
Hemiplegia/hemiparesis |
Increased intracranial pressure |
Abnormality of speech or vocalization |
Dysarthria |
Dysgraphia |
Depression |
Irritability |
Disturbed sensory perception |
Anxiety |
Hallucinations |
Atypical behavior |
Attention deficit hyperactivity disorder |
Memory impairment |
Dyskinesia |
Gait disturbance |
Migraine |
Developmental regression |
Seizure |
Paresthesia |
| Disease(s) Associated with SMAD4 | ||||||||||||||||||||||||||||||||||
| hereditary hemorrhagic telangiectasia | ||||||||||||||||||||||||||||||||||
| juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome | ||||||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | abnormal rhombomere morphology |
abnormal hindbrain development |
decreased Purkinje cell number |
abnormal cerebellar molecular layer |
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| Availability | Mouse Genotype | ||||
| Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Nes-cre)1Atp/0 (conditional) |
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| Smad4tm1Rob/Smad4tm1.1Rob Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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